Sclerosis lateralis amyotrophica

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Sclerosis lateralis amyotrophica[1] (ICD-10: G12.2) est gravis morbus systematis nervosi, accurate neuronum motoriorum defectio. Hic morbus, qui corpus degenerat dum progreditur, adhuc hodie sanari non potest, et ad extremum in mortem ducit. Primum hunc morbum descripsit Ioannes Martinus Charcot, medicus Francicus.


In Italia multi pedilusores hoc morbo mortui sunt, ergo putatur scilicet etiam venena contra mala gramina, quae in pediludii campis utuntur, sclerosem lateralem amyotrophicam generare possunt.[2] Non est remedia plena at ad morbum allevandi, technologia adiuvans vel communicatio augmentans et alternativa utetur.?




Index






  • 1 Symptomata et signa


  • 2 Neuropathologia


  • 3 Homines notabiles affecti


  • 4 Notae


  • 5 Nexus interni


  • 6 Nexus externi





Symptomata et signa |


Neuronibus motoriorum degeneratis et superioribus et inferioribus symptomata ac signa musculorum et tenuitas (atrophia) et infirmitas corporis apparent. Cum initium non rare obscure esset, in morbi cursu symptomata muscularia progrediantur. Adhuc omnibus rationibus infrenata, postremo morbus quamcumque gubernationem motuum voluntariam affert, quamquam et vesicae et tractūs gastrointestinalis et musculorum bulbi oculi externorum gubernatio saepe usque ad extremum intacta restabit[3].



Neuropathologia |


Decursu morbi proteinum TDP-43 momentum maius habere videtur[4].



Homines notabiles affecti |




  • Ludovicus Gehrig (1903–1941)


  • Lucas Coscioni (1967–2006)


  • Guarnerius Hollweg (1936–2007)


  • Stephanus Borgonovo (1964–2013)


  • Stanislaus Gross (1969–2015)


  • Georgius Immendorf (1945-2007)


  • Stephanus Hawking (1942-2018)



Notae |




  1. ↑ Dissertatio, www.researchgate.net.


  2. ↑ M. Vinceti, I. Bottecchi, A. Fan, Y. Finkelstein, J. Mandrioli (2012): Are environmental exposures to selenium, heavy metals, and pesticides risk factors for amyotrophic lateral sclerosis? In: Rev Environ Health, vol. 1, pp. 19-41.


  3. ↑ Hobson E. V., McDermott C. J. (2016). "Supportive and symptomatic management of amyotrophic lateral sclerosis". Nat Review of Neurology 12: 526-38 .


  4. ↑ Brettschneider J., Del Tredici K., Toledo J. B., Robinson J. L., Irwin D. J., Grossman M., Suh E., Van Deerlin V. M., et al. (2013). "Stages of pTDP-43 pathology in amyotrophic lateral sclerosis". Annals in neurology 74 (1): 20-38 


Nexus interni



  • Chromosomatis 9 margo lectoria aperta 72

  • Tractus pyramidalis



Nexus externi |







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