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1 $begingroup$ I have sensors (pyranometers that consist of thermopiles and measure sun irradiation) that ouput a low voltage signal so I need to amplify them using an instrumentation amplifier. I have chosen the AD8237 for this task: Datasheet Im using a gain of 100 to amplify the initial low voltage signal (ranging 0-20mV) to 0-2V range. Im then feeding the amplified signal to the ADC (MCP3422): Datasheet My sensor values change very slowly and I will read out the digitized ADC values only once every second, so speed is not important in my case. Now as pointed out in the accepted answer in this question I need a filter between the IN-Amp and the ADC to filter the noise. In many ADC-datasheets a simple passive RC-filter is suggested between the INA and ADC. I did quite some research and I still have som