Receptorium GABA







Receptorii GABA subtypus A est receptorium ionotropicum.


Receptoria GABA sunt grex receptoriorum neurotransmissoris, quae in vertebratorum systemate nervoso centrali ab neurotransmissore inhibente GABA stimulantur[1]. Adhuc tres classes inventae sunt: Receptoria GABAA ac receptoria GABAA-ρ ionotropicae enim et receptoria GABABproteino G copulata. Nimirum velocitates eorundem divertunt: Cum ionotropica celeriora essent, ita proteino G copulatum GABAB tardius est.


Per receptoria GABA in vertebratorum systemate nervoso centrali operationes inhibentes principales[2] excellunt.


Praeterea receptoriis GABA in iecoris hepatocytis quoque et cholangiocytis ductūs biliaris[3] functiones enim, velut in pancreate[4], sunt.





Acidum γ-aminobutyricum, "GABA" abbreviatum




Index






  • 1 Receptoria GABAA


  • 2 Agonistae


  • 3 Antagonistae


  • 4 Notae


  • 5 Nexus interni





Receptoria GABAA |


Quodque receptorium GABAA est canalis ionticus imprimis chloridi, proinde ionotropicum receptorium.[5] Subunitates receptorii variae descriptae sunt. Alkaloidum bicucullinum antagonista selectivus competitivusque haec receptoria inhibit.



Agonistae |



  • Diazepamum (non selectivus)[6]


Antagonistae |



  • Bicucullinum (GABAA, selectivus et competitivus)


Notae |




  1. ↑ Watanabe M., Maemura K., Kanbara K., Tamayama T., Hayasaki H. (2002). "GABA and GABA receptors in the central nervous system and other organs". International Revue of Cytology 213: 1-47 


  2. ↑ Olsen R. W., Tobin A. J. (1990). "Molecular biology of GABAA receptors". FASEB journal 4 (5): 1469-80 


  3. ↑ Wang S., Zhang L., Liu C., Lu W. Y. (2017). "Protective roles of hepatic GABA signaling in liver injury". International journal of physiology, pathophysiology and pharmacology 9 (5): 153-6 


  4. ↑ Dong H., Kumar M., Zhang Y., Gyulkhandanyan A., Xiang Y. Y., Ye B., Perrella J., Hyder A., Zhang N., Wheeler M., Lu W. Y., Wang Q. (2006). "Gamma-aminobutyric acid up- and downregulates insulin secretion from beta cells in concert with changes in glucose concentration". Diabetologia 49 (4): 697-705 


  5. ↑ Olsen R. W., Sieghart W. (2008). "International Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: classification on the basis of subunit composition, pharmacology, and function. Update". Pharmacol Rev 60 (3): 243-60 .


  6. ↑ Atack J. R. (2005). "The benzodiazepine binding site of GABA(A) receptors as a target for the development of novel anxiolytics". Expert Opin Investig Drugs 14 (5): 601-18 


Nexus interni



  • Anxietas

  • Benzodiazepinum




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