Morbus Alzheimerianus
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Imago cerebri hominis a morbo Alzheimeriano aegrotati ab Alzheimer ipso anno 1911 facta.
Morbus Alzheimer[1] vel Alzheimeranus[2] est morbus neurodegenerativus chronicus et communissimum dementiae genus. Hic morbus, qui degenerat dum progreditur, adhuc hodie sanari non potest, et ad extremum in mortem ducit. Causa adhuc nescitur, quod usitate senescendi non est, etiamsi medicamenta sumi possunt ad symptomata mollienda. Appellatur ex Aloysio Alzheimer, psychiatro, neurologo et neuropathologo Germanico, qui anno 1906 morbum investigavit.
Index
1 Causae
1.1 Hypothesis cholinergica
1.2 Architectura genetica
2 Diagnosis
2.1 ICD-10: Dementia et morbus Alzheimerianus
2.2 Valores ex liquore cerebrospinali investigandae
3 Therapia
4 Nexus interni
5 Notae
6 Bibliographia
7 Nexus externi
Causae |
Quo pacto affectus pathologici nascuntur et dein intus in cerebro crescunt nunc etiam inexplicatum permanent.
Ad causas explicandum tamen plures hypotheses pronuntiatae sunt, exempli gratia hypothesis cholinergica aut hypothesis amyloidorum aut hypothesis Tau. Etiam inflammatio in enumeratione causarum applicata est[3]. Nonnulli vero casus morbi Alzheimeriani in commutationes geneticas reduci possunt.
Hypothesis cholinergica |
Hac vetissima, ad quem pleraeque substantiae Morbum Alzheimerianum medendi hodiernae referuntur, eum synthesi reducta neurotransmissoris Acetylcholini explicari posse magnopere suggesta est.
Quamquam haec hypothesis, cum facile intellegi possit, iam diu dubitationem attulit.
Architectura genetica |
Increscunt argumenta, quae genetica morbi Alzheimeriani in forum disputationum scientificorum proponunt. Iam non solum nonnullae mutationes in quibusdam familiis, sed etiam polymorphismi nucleotidi singularis[4]genomi momenta processus morbi at protectiva[5] habent.
Diagnosis |
Secundum ICD-10 Morbus Alzheimerianus est morbus neurologiae (G30); et dementia (F00) mutationibus intracerebralibus causa symptoma. Adhuc nonnulla etiam signa, in parte incerta, et e sanguine et ex liquore cerebrospinali nominantur[6].
ICD-10: Dementia et morbus Alzheimerianus |
Ante mortem diagnosis restat incerta. Symptomata sunt dementia, initium latens, progressus tardus. Non ad morbum Alzheimerianum attinent hemiparesis et initium apoplecticum, neque hypothyreosis, hydrocephalus, hypercalcaemia, haematoma subdurale.
Valores ex liquore cerebrospinali investigandae |
Saepe investigari possunt valores haec:
- Aß(1-42)
- proteinum tau
- phospho-tau
Therapia |
Sanatio morbi per medicamenta adhuc vix feliciter apparet. In tractandano symptomata quidem morbi Alzheimeriani quaedam medicamenta excogitata sunt, quae interdum - falsiter - antidementiva vocantur, sed lenimentum applicari possunt. Ea antidementiva dicta communiter sunt inhibitores enzymi acetylcholini esterasis.
Nexus interni
- Amyloidum beta
- Aphasiologia
- Beta-secretasis 1
Notae |
↑ "Dementia in morbo Alzheimer ... praecox ... tardiva [etc.]": vide F00-F09 apud Stetoskop
↑ "Morbus Alzheimerianus": Tuomo Pekkanen, "De Morbo Alzheimeriano," Nuntii Latini, 26 Iulii 2002.
↑ Heneka M. T., Carson M. J., El Khoury J., et al. (2015). "Neuroinflammation in Alzheimer's Disease". The Lancet. Neurology 14 (4): 388-405
↑ Lee S. H., Harold D., Nyholt D. R. et al. (2013). "Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis". Humam molecular genetics 22 (4): 832-41
↑ Wolf A. B., Caselli R. J., Reiman E. M., Valla J. (2013). "APOE and neuroenergetics: an emerging paradigm in Alzheimer's disease". Neurobiology of aging 34 (4): 1007-17
↑ Olsson B., Lautner R., Andreasson U., Öhrfelt A., Portelius E., Bjerke M., Hölttä M., Rosén C., Olsson C., Strobel G., Wu E., Dakin K., Petzold M., Blennow K., Zetterberg H. (2016). "CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis". The Lancet. Neurology 15 (7): 673-84
Bibliographia |
- Alzheimer's Disease: Unraveling the Mystery. US Department of Health and Human Services, National Institute on Aging, NIH. 2008
- Can Alzheimer's Disease Be Prevented?. US Department of Health and Human Services, National Institute on Aging, NIH. 2009
- Caring for a Person with Alzheimer's Disease: Your Easy-to-Use Guide from the National Institute on Aging. US Department of Health and Human Services, National Institute on Aging, NIH. 2009
- Cummings, J. L., J. C. Frank, D. Cherry, N. D. Kohatsu, B. Kemp, L. Hewett, et B. Mittman. 2002. Guidelines for managing Alzheimer's disease: Part I: Assessment. American Family Physician 65(11):2263–2272. pmid 12074525.
- Cummings, J. L., J. C. Frank, D. Cherry, N. D. Kohatsu, B. Kemp, L. Hewett, et B. Mittman. 2002. Guidelines for managing Alzheimer's disease: Part II: Treatment. American Family Physician 65(12):2525–2534. pmid=12086242.
- Russell, D., S. Barston, et M. White (19 Decembris 2007). "Alzheimer's Behavior Management: Learn to manage common behavior problems". helpguide.org
Nexus externi |
 | Vicimedia Communia plura habent quae ad morbum Alzheimerianum spectant. |
"Cognitive Test for Alzheimer's". NLM video .mw-parser-output .existinglinksgray a,.mw-parser-output .existinglinksgray a:visited{color:gray}.mw-parser-output .existinglinksgray a.new{color:#ba0000}.mw-parser-output .existinglinksgray a.new:visited{color:#a55858}
(Anglice)
"Healthy aging"
(Anglice)
Alzheimer's Disease Research Centers, www.nia.nih.gov (National Institute of Aging)
Alzheimer's Disease Education and Referral (ADEAR) Center, www.nia.nih.gov (National Institute of Aging)
Alzheimer's Association, www.alz.org (Alzheimer's Association)
UCSF Memory and Aging Center, memory.ucsf.edu (University of California San Francisco)
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